基于四水听器的充水弹性管声速测量方法

实验室中水声材料声学参数的测量主要在水声声管中进行。管内平面波声速是正确测量这些参数的基础。该文提出一种基于四水听器结合不同边界的测量充水弹性管中声速的新方法。该方法利用4个固定位置处的水听器,采用最小二乘的方法,使得两组水听器分别得到的声管末端入射波声压差值的平方最小的声速即为管内平面波声速。该方法利用单频信号,在每一频率点均可测得声速,可以在任一种声管末端边界下进行测量,同时无需知道各水听器到边界的精确距离,在文中的3种边界下声速测量结果具有很好的一致性,实验操作简单、误差很小。该方法的仿真结果与管内声速的理论值吻合得很好,同时实验测量结果与仿真值之间的误差很小,证明了方法的准确性以及鲁棒性,为声管声速测量提供一个很好的思路。     

Computer-aided molecular design of (E)-N-Aryl-2-ethene-sulfonamide analogues as microtubule targeted agents in prostate cancer

Microtubules are tube-shaped, filamentous and cytoskeletal proteins that are essential in all eukaryotic cells. Microtubule is an attractive and promising target for anticancer agents. In this study, three-dimensional quantitative structure activity relationships (3D-QSAR) including comparative molecular field analysis, CoMFA, and comparative molecular similarity indices analysis, CoMSIA, were performed on a set of 45 (E)-N-Aryl-2-ethene-sulfonamide analogues as microtubule-targeted anti-prostate cancer agents. Automated grid potential analysis, AutoGPA module in Molecular Operating Environment 2009.10 (MOE) as a new 3D-QSAR approach with the pharmacophore-based alignment was carried out on the same dataset. AutoGPA-based 3D-QSAR model yielded better prediction parameters than CoMFA and CoMSIA. Based on the contour maps generated from the models, some key features were identified in (E)-N-Aryl-2-arylethene-sulfonamide analogues that were responsible for the anti-cancer activity. Virtual screening was performed based on pharmacophore modeling and molecular docking to identify the new inhibitors from ZINC database. Seven top ranked compounds were found based on Gold score fitness function. In silico ADMET studies were performed on compounds retrieved from virtual screening in compliance with the standard ranges.     

利用混合FE-SEA方法的前围隔声性能优化设计*

为了提升某重型商用车前围的隔声性能,建立了用于分析前围传递损失的有限元-统计能量分析(FE-SEA)模型。针对前围结构复杂的特点,依据FE-SEA模型建模原则,提出了通过在表面创建声腔来确保能量在模型中的正确传递路径。将仿真结果与测试值对比,二者误差小于1.6 dB(A),验证了FE-SEA方法的准确性。用吸声材料与隔声材料复合设计前围声学包,采用正交试验法对前围声学包进行优化设计并对各个试验方案进行仿真计算。对仿真结果进行极差分析与方差分析,选出了在传递损失、重量和厚度三方面达到最佳平衡的声学包:毛毡(10 mm)+EPDM隔声垫(2 mm)。结果表明,优化后的前围传递损失在测试频率315 Hz～2000 Hz范围内最小提升了3.8 dB(A),最大提升了7 dB(A),前围的隔声性能得到较大的提升。     

Enhancement of pupil-masked wavelength-scale gas-filled flat acoustic lens based on anomaly apodization effect

In this letter, the improvement in focus by the use of a pupil mask produced in an acoustic mesoscale cuboid particle filled with CO₂ is reported. Thereby, the result shows that the pupil mask increases the sound intensity and also increases the resolution (or a reduction of the full width at half maximum, FWHM) in focus compared to the non-masked one. These results are important because they confirm the effect of abnormal amplitude apodization for a one-wavelength dimension acoustic lens and demonstrate that it is possible to improve sound focusing of a cuboid gas-filled lens with one wavelength dimension. This is the smallest size of an acoustic lens ever considered in this type of literature, with side dimensions of the cube equal to one wavelength and a diameter to focus ratio of 2.5, the sound amplification in focus is 5.4 dB at 4125 Hz, with the resolution near to the diffraction limit.     

基于深度约束的声速估算方法*

高精度的声速剖面数据是提高水下定位精度的关键。在无法精确获得声速剖面数据的情况下,该文提出了一种基于深度约束,同时根据浮标与水下目标的空间几何距离进行有效声速估算的方法。通过仿真模拟,将该文提出的方法与加权平均声速法、泰勒级数展开法和等效声速剖面法的定位结果进行对比分析。结果表明,新方法不需要依靠声速剖面数据,通过深度约束可有效地估算出声速值,其定位精度与等效声速结果相当,极大地提高了无声速剖面数据下的水下定位精度。     

膨胀腔类超材料的传递损失研究*

声学超材料及结构已被广泛研究,其超结构通常利用3D打印技术实现,当结构刚度较小或者面积较大时,由声固耦合所导致的声学效果与设计不符的情况广泛存在。本文针对含有膨胀腔类的超材料,研究了声固耦合对其声学性能的影响,采用有限元计算结合阻抗管实验的方法,得到其传递损失,分析了声固耦合现象对传递损失的影响。结果表明：薄壁膨胀腔结构的作用频率范围与只考虑声学理论计算的设计不符,声固耦合现象对传递损失产生显著影响;采用增加膨胀腔壁厚、减少膨胀腔内径或选择金属材料的方式,都可以使得声固耦合现象对传递损失的影响减小;仿真结果与实验结果基本吻合。该研究结果说明：对于膨胀腔类超材料,当刚度较小或者面积较大时,对其进行声固耦合分析是完全必要的。     

Using a virtual skeleton to increase printability of topology optimized design for industry-class applications

This article broadens the scheme previously developed to associate topology optimization with additive manufacturing through the use of a virtual skeleton, consisting in solving the same physical problem with a discrete approach and then with a continuum one. This procedure for 3D designs is applied to various domain geometries, to demonstrate its pertinence on high-resolution industrial cases. An algorithm searching for the best printing direction, exploring the solid angle, is also described and validated; the surface-shaped presentation of the result allows immediate understanding of the influence of the discrete problem parameters, while its running time is much lower than a unique continuum optimization simulation, which proves the attractiveness of the method. In the three examples studied, the procedure outputs exhibit greater printability than the ones produced by traditional methods in each of the printing direction tested, albeit responsibility is left to the final user to choose his best trade-off. Furthermore, the unprintable zones are readily displayed to be either reworked or supported. Explanations about increase of convergence likelihood on discrete structures despite the geometry complexity of an industrial application are also provided and demonstrated.     

瞬时环流反馈均流策略在EAST快控电源中的应用

在EAST 快控电源中采用瞬时环流反馈引入虚拟电阻的均流控制策略,可大大增加并联逆变器之间等效输出阻抗的实部,有效提高对环流低频分量的抑制能力。仿真和实验结果验证了该控制策略的可行性和有效性。     

基于分子描述符和机器学习方法预测和虚拟筛选乳腺癌靶向蛋白HEC1抑制剂

HEC1(癌症高表达蛋白)是纺锤体检查点控制、着丝粒功能、细胞存活的关键的有丝分裂调节器,与原发性乳腺癌的不良预后有关.筛选具有高亲和力的HEC1新型抑制剂对探索乳腺癌的靶向治疗具有重要意义.本文从结构多样性的化合物库中筛选HEC1抑制剂.通过对分子描述符的特征筛选,采用支持向量机(SVM)和随机森林(RF)方法分别对HEC1抑制剂和非抑制剂建立了分类模型.经对比, RF模型显示了更好的预测精度.我们采用RF模型对HEC1抑制剂进行了虚拟筛选,从“in-house”实体库筛选得到2个潜在的HEC1抑制剂分子.随后对筛出的化合物进行了体外活性实验,发现对乳腺癌细胞株MDA-MB-468和MDA-MB-231均有一定程度的抗肿瘤活性.研究结果表明,机器学习方法对于设计和虚拟筛选HEC1抑制剂有良好的效果.     

中国筝的声功率级测试

筝是中国古老的弹弦乐器。但迄今为止,对其声功率级一直未进行科学的测定。本文在一混响室内根据ISO及GB标准,对二十一弦筝的声功率级进行了首次测定。两位资深乐师在混响室内分别演奏各自的乐器,通过围绕乐师和乐器布置的四通道测试设备,对筝所辐射的声功率级和动态范围进行测定。测试结果表明,中国筝在以不同力度演奏单音、音阶和乐曲时所辐射的声功率级及其频率特性均有所不同。考虑到乐器演奏音阶时所辐射的声功率级及其动态范围与演奏乐曲时的声功率级接近,并且,音乐的空间感也大都在乐器以f力度演奏乐曲的强音标志乐段时最为显著,故此我们建议中国筝所辐射的声功率级用其以f力度演奏音阶时的平均声功率级表示。本文测试的两架中国筝以f力度演奏音阶时的平均声功率级为85.9dB。文中不仅首次公布了中国筝声功率级的测试结果,并且所介绍的测试方法对其它乐器声功率级测试也具有借鉴意义。民族乐器所辐射的声音性能的确定是民族音乐厅堂音质研究的基础。